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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations
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In the 3-KO and WT groups, male mice aged 1214 weeks were divided into three subgroups including: saline control, AOD9604 administered at a dose of 250 g/kg/day, and hGH administered at a dose of 1 mg/kg/day
It is highly bound to plasma proteins and its elimination half-life is 24 hrs, eliminated in the urine
Research facilities should store these compounds in cool dry conditions away from direct sunlight to preserve chemical stability and consistent results
Side note: Researchers think that lactic acid bacteria produce biogenic amines as a defense mechanism in order to withstand acidic environments
